The human1-8Dgene (IFITM2) is a novelp53independent pro-apoptotic gene

C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution.

The STAT3 transcription factor is an important initiator of mammary gland involution in the mouse. This work shows that the STAT3 target gene CCAAT/enhancer binding protein delta (C/EBPdelta) is a crucial mediator of pro-apoptotic gene expression events in mammary epithelial cells. In the absence of C/EBPdelta, involution is delayed, the pro-apoptotic genes encoding p53, BAK, IGFBP5 and SGP2/cl...

The pro-apoptotic factor Nix gene is co-expressed with Bcl-xL during terminal erythroid differentiation

BAD is a pro-survival factor prior to activation of its pro-apoptotic function.

The mammalian BAD protein belongs to the BH3-only subgroup of the BCL-2 family. In contrast to its known pro-apoptotic function, we found that endogenous and overexpressed BAD(L) can inhibit cell death in neurons and other cell types. Several mechanisms regulate the conversion of BAD from an anti-death to a pro-death factor, including alternative splicing that produces the N-terminally truncate...

BAX pro-apoptotic gene alterations in repeated pregnancy loss

INTRODUCTION Recurrent pregnancy loss (RPL) is a critical medical problem in about 0.5-2% of women. The molecular genetic background for spontaneous abortion is being increasingly understood, and some polymorphisms associated with it have been reported. This study investigates alterations of the Bax gene as a pro-apoptotic gene in women with idiopathic RPL. MATERIAL AND METHODS The frequency ...

Psychosexual Differentiation in the Human1

This review presents the major findings in studies on humans of chromosomal, gonadal, prenatal hormonal and environmental contributions to sex dimorphic behaviors. The hypotheses derived from these studies are evaluated. Findings relevant to possible biological antecedents in the formation of gender identity, gender role behaviors, sexual orientation and “parenting” behaviors are reviewed and c...